https://einsteinneurosurgery.org/contact daily 0.75 2021-09-28 https://einsteinneurosurgery.org/home daily 1.0 2024-04-24 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/0f8c5670-e3e2-446a-acb1-7a6e82ce6276/Eskandar_Emar_MD_Portraits_2021_10_08_151_V3.jpg Home Dr. Emad Eskandar MD, MBA | Jeffrey P. Bergstein Chair Leo M. Davidoff Department of Neurological Surgery https://einsteinneurosurgery.org/labmembers daily 0.75 2025-08-29 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/3cc0c983-dcb4-4826-b485-c9d2f8481ef1/Eskandar_Emar_MD_Portraits_2021_10_08_151_V3.jpg Lab members Dr. Emad Eskandar, MD, MBA | Jeffrey P. Bergstein Professor and Chairman https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730402080656-8N6LWGR3UQUW4KQWGVZC/image.jpg Lab members Hector J. Asencio III, MSc | Research Technician https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1694450372855-SY0H8FA38D8IY7BAD9A2/headshot.jpg Lab members Dr. Nathan Killian, PhD | Assistant Professor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1721169172144-SN2TA0JB80K1X9VET7NZ/IMG_2686.jpg Lab members William Kemball-Cook, BS | Research Technician https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1699568777962-O4EZM4KADXHI9TVZPGG1/Kaskan_Peter_PhD_small%25281%2529.jpg Lab members Dr. Peter Kaskan, PhD | Assistant Professor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/ba6f808d-c264-4e02-9dac-86ef01bd694c/Personal+Phot+NY+11Jul2020.jpg Lab members Dr. Jinan Behnan, PhD | Assistant Professor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730999873982-RSH8ICS6Z59I8B2HA0J6/Himes%2BProfile%2BPic.jpg Lab members Dr. Benjamin T. Himes MD, PhD, MHS | Assistant Professor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730999828359-DM7NF4YKFKXE5EQ3JWAF/Falcone_Rosella_PhD_Portraits_2024_9_4_4.jpg Lab members Dr. Rossella Falcone, PhD | Assistant Professor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1742923199317-Q74ZS4J6UE4S2WOKVVZ7/Mohammad%2BAsad.jpg Lab members Dr. Mohammad Asad, PhD | Instructor https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730402896195-ZU1LX5K0Q9M4QKMY993I/Untitled-1.jpg Lab members Dr. Keyvan Ghadimi, MD | Postdoctoral Research Fellow https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1706805820293-OY6YZ4GX6LW8PJ0TMPER/Headshot2023.jpg Lab members Chaim Feigen, MS | MD student, PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730999908977-581FGU6QIWR4E5BIGSU1/Bader_Edward_Portraits_2024_5_20_8.jpg Lab members Dr. Edward R. Bader, MBChB MS | PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/d16c7d58-0a8d-4480-9b40-37b55df92c9f/CB_headshot_use.png Lab members Cetta Brusco, MS | MD-PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1706805775157-CZH0VCSKEGLMLE5OIYZ4/EB%252BPhoto%252B2022.jpg Lab members Ethan Baratz, MS | MD-PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1729716197993-FXVQMDDNDJ2E0471VLBG/Headshot%25281%2529.jpg Lab members Minori Aoki, MS | PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1730922248657-WYL2EHWMW4X6ILQ46OWN/RC_profile.jpg Lab members Roozie J.J. Coenen, MS | PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1731005931382-KAHASHM3PGVQ0K220GC9/IMG_6330.jpg Lab members Emily Schoenblum, MS | PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1754593747024-NDKR6XPJU6FPF4YIIC6T/Dorrian_Headshot.jpg Lab members Luke Dorrian, BS | PhD Student https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1726865470671-VG9B7Y2SA81S02LWDLB4/PHOTO-2024-09-20-13-22-52.jpg Lab members Imane Abbas, MD | Research Technician https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1759339066624-RLND6E6UCCNJKODG7KWB/IMG_4516.png Lab members Carly Baker, MS | Research Technician https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1756481498238-TFU71DZPT9XO2WKIEEJD/MIH_headshot.jpg Lab members Mar I. Hinestroza, BA | Research Technician https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1759782086421-7JZSVX7UUKQAN283AF2Y/QS1_1335.jpg Lab members Ashley Williams, BS | Research Technician https://einsteinneurosurgery.org/kaskanlab daily 0.75 2025-12-04 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/890594d3-1a4d-464f-9c34-dcf63596823b/MEDA_Neurosurgery_Kaskan_Lab_2023_12_14_14.jpg Kaskan Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/b67a03e1-d6eb-4188-a23d-b238fcfb3f62/Kaskan_Peter_PhD_small%282%29.jpg Kaskan Lab Dr. Peter Kaskan PhD | Assistant Professor Department of Neurological Surgery Department of Neuroscience peterdotkaskan@einsteinmeddotedu https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/8cdbe467-a90a-4cfa-ab5c-2ab4499755b4/Dorrian_Headshot%281%29.jpg Kaskan Lab https://einsteinneurosurgery.org/eskandarlab daily 0.75 2024-04-08 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/3cc0c983-dcb4-4826-b485-c9d2f8481ef1/Eskandar_Emar_MD_Portraits_2021_10_08_151_V3.jpg Eskandar Lab Dr. Emad Eskandar MD, MBA | Jeffrey P. Bergstein Chair and Professor Leo M. Davidoff Department of Neurological Surgery Dominick P. Purpura Department of Neuroscience https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1632843482813-5ZTT516R3YQIFAPJSFE2/caudate+stim.png Eskandar Lab - Microstimulation to enhance learning The Nucleus Basalis and Medial Forebrain Bundle are key components of the brain circuitry of learning. The Nucleus Basalis provides cholinergic innervation to the entire cortex and can coordinate cortex during cogntive processes. Degeneration of the Nucleus Basalis occurs early in neurodegenerative disorders, including Alzheimer’s Disease and Parkinson’s Disease, suggesting that its loss may play a significant role in the cognitive deficits seen in these disorders. The Medial Forebrain Bundle carriers projections from the Nucleus Accumbens to the prefrontal cortex and is thus an appealing target for neuromodulation, with early reports suggesting that DBS of the medial forebrain bundle is effective in modulting cognitive processes. By investigating the neurophysiology of theses structures, we aim to design novel deep brain stimulation treatment paradigms to enhance cognition. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1632844179145-K95AIGUFH1Q2DZM29QJE/maserr.png Eskandar Lab - MASER Technology for Large Scale Recording and Modulation of Brain Activity Our lab is designing the next generation of brain imaging. Using paradigm-shifting breakthroughs in MASER technology (Microwave Amplification by Stimulated Emission of Radiation), we are designing systems that can provide brain-wide activity monitoring at a scale far more precise than current systems, with the potential for non-invasive, reversible modulation of neuronal activity. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1632842921936-ZTWAU9VO799E7LE1VFEU/addiction+fig.png Eskandar Lab - Neurophysiology of Addiction There is extensive overlap between the neural circuits and physiological mechanisms underlying learning and addiction. Addictive substances have been shown to hijack the brain’s intrinsic reward systems, leading to an “artificial reward”, biasing individuals to addictive behaviors. We are investigating brain regions co-involved in learning and addiction, including the Nucleus Accumbens and Dorsolateral Prefrontal Cortex, to elucidate the neurophysiology of addiction and derive deep brain stimulation paradigms to target addictive behavior. https://einsteinneurosurgery.org/behnanlab-1 daily 0.75 2021-09-15 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1631738063385-M81SAAAESMOQYKK8XXCT/Personal+Phot+NY+11Jul2020.jpg Behnan Lab (Copy) - Jinan Behnan, PhD | Assistant Professor Linkedin | Researchgate Our aim is to characterize the tumor stroma in Glioblastoma (GBM), the most aggressive and treatment-resistant brain tumor. We were the first in the world to report the recruitment of endogenous Mesenchymal stem cells (MSCs) in glioma (Behnan et al. Stem Cells, 2014) and characterize the mesenchymal subtype in GBM patients (Behnan et al. Oncogene, 2017). Our observation indicated that the Mesenchymal subtype is divided into two subgroups, one induced by recruited cells and microenvironment, and another tumor cell per se expressing Mesenchymal properties suggesting brain derived MSCs/perivascular cells as the origin of the tumor origin (Behnan et al. Brain 2019; Behnan et al. Oncogene, 2017). Our particular focus is on understanding the biology of recruited noncancerous cells to the tumor, mainly primarily the immune cells and mesenchymal stem cells/perivascular progenitors in different GBM subtypes, and to. Define the origin of different recruited cell population, and its interaction with cancerous cells to solve the complexity and heterogeneity of this devastating tumors. Simultaneously, we are working on establishing a translational therapeutic treatment for GBM through combining immunotherapy with other target therapy to change the immunosuppressive microenvironment and eradicate cancer cells. With our extensive knowledge in human Glioma stem cells (Behnan et al. Sci Rep, 2016), we aim to establish drug screening library to test the specificity of drug response among different GBM subtypes. We will be using immune competent glioma mouse models, transgenic models utilizing different techniques including flow cytometry, confocal microscopy, 2 photon microscopy, low threshold ultrasound. We are looking for collaborative integrative approaches with other investigators to reach innovative treatment and achieve our ultimate goal in finding treatment for brain tumor patients. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1631738351461-QASVZK5T8C0VWKR8I7AL/Identification-of-a-marker-panel-that-distinguishes-sphere-cultures-from-serum-cultures_W640.jpg Behnan Lab (Copy) - Behnan Lab: Tumor Stroma I have more than 12-years’ experience in the glioma field. I did my Postdoc in the Ernfors' lab at the Karolinska Institute, Sweden. I obtained a PhD in Tumor Biology from Oslo University, Norway. I graduated from Research School in Stem Cell Biology, Lund Stem Cell Centre, Sweden, and I had Master degree in Biomedicine, Sweden. I have broad expertise in tumor stroma, preclinical trials in immunotherapy, working with epileptic and glioma patient samples and using different techniques ex. animal surgery, small animal irradiation, vaccination, Flow cytometry, confocal microscopy, and establishing primary cell culture from different human and mouse tissue. I am the leading and corresponding author on 5 of my publications. I’m serving as referee for high quality peer-reviewed journals (Brain, Stem Cells, Cancer Research, NeurOncology etc). As well, I have experience in advancing anti-inflammatory and anti-cancer treatments into clinical trials. I was awarded Marie Curie Fellowship 2019. https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847459679-XKODS8BCCXEYKBHGKJQC/20140301_Trade-151_0124-copy.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847458993-KBYNGSGUCGZWV223MRFF/20140228_Trade+151_0046.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847458319-DK4513Y3XD3GKBA1OOB6/Aro+Ha_0428.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847456616-6RFY2R4EBQWZHCZQMJE9/Aro+Ha_0010.jpg Behnan Lab (Copy) https://einsteinneurosurgery.org/killianlab daily 0.75 2024-07-24 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/5991cbc5-ccad-43ad-acb5-8d6fb814e6cd/headshot.jpg Killian Lab - Make it stand out Dr. Nathan Killian PhD | Assistant Professor Department of Neurological Surgery | Nathaniel.killian@einsteinmed.edu https://einsteinneurosurgery.org/behnanlab daily 0.75 2024-02-27 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1632938085488-CIH5IFLJVCI2LBLJKFXV/7+Screenshot+2021-09-28+165252.png Behnan Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1632862858047-VD3T748REB2V9GF314Y9/Personal+Phot+NY+11Jul2020.jpg Behnan Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/88a14eb3-9b68-4444-9cde-c5d6ccd9daa8/Fig5.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/6bcaf2e7-a1c3-4f2a-8927-fe394b3bb257/GBM+immunotherapy.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/651b83df-37bf-4161-8700-2c89661ef230/Fig6Recruited+MSC.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/8f1a86fa-5a9e-48ca-a819-139ff2488684/2GSC+schematic.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/5b9375df-79a6-4c3f-99a6-406fec780e61/Fig7Recruited+MSC.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/9ef48fc1-2e16-4c56-9f63-6ca39dcd2442/3Human+GBM.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/751bbfb8-08fd-4a89-b580-02858a08e046/Fig8The+BT-MSCs+are+of+host+origin+recruited+to.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/de7fa42b-00ce-4461-bbb6-2fd59a841e19/4Human+GBM.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/a3a006f9-2d14-4d31-8b05-7042fa5c61b4/Fig13+Induced+Mes+signature+in+vitro.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/232a9b3f-08ab-416a-8138-f41335b7606c/GBM+for+Jinan.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/4b79e66d-4af4-4001-83cc-5eba45548d47/Fig14Induced+Mes+signture+in+vitro.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/53c457e9-2efe-49e1-a94e-758800234dbe/5+Screenshot+2021-09-28+164920.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/ea02f780-b399-4d0f-b841-4a9554455ed0/6+Screenshot+2021-09-28+165220.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/e568d78d-7d71-449c-ae06-44677fd924d7/Fig+4+spheroid.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/40487cb2-2dc5-480a-9275-3d4aa9dab49d/7+Screenshot+2021-09-28+165252.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/77d553bd-2117-4f59-9daa-015b34bb2bb3/8In+vivo+tumorigenecity.jpg Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/2ac0a739-d333-4c4f-9187-166cf07b0e02/Fig+10+GBM-MSC+CD105.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/65af4f7a-0366-442e-ad00-a0e1c38201ef/2+HUman+GBM.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/b6d4a3bd-bfcd-42e2-bdec-6941e42ffbf4/Fig+11+GBM+MSC+aSMA488.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/19a3c8b9-46de-4dd2-bb2f-d03b8b1e33ba/M2+.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1c772219-c513-44ce-9bba-4468c8d522e6/Fig9+GBM+patien-MSC+Endosialin.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/00b1dfff-cc6e-4f5f-b1cb-f7aeb2435a5d/M3+.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/63911b52-1206-45d2-8383-21a7c972c25b/Fig15+Mes+in+vivo.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/cf83f7b5-0489-447a-951c-0755a80d49f1/method+graphical+abstract.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/35bfb37d-fda0-4f50-b2f5-0613c37cb396/Screenshot+2021-09-22+182113.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/ebe01d99-bf0f-476f-8d1c-46e663c2423e/Screenshot+2021-09-22+182158.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/c871d7a2-3295-40c0-9f75-55ff6a6c5ba2/Screenshot+2021-09-22+182251.png Behnan Lab https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/ff65e42b-1c8b-4844-9d1a-231daecb9456/Screenshot+2021-09-22+182313.png Behnan Lab https://einsteinneurosurgery.org/behnanlab-2 daily 0.75 2021-09-15 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1631738063385-M81SAAAESMOQYKK8XXCT/Personal+Phot+NY+11Jul2020.jpg Behnan Lab (Copy) - Jinan Behnan, PhD | Assistant Professor Linkedin | Researchgate Our aim is to characterize the tumor stroma in Glioblastoma (GBM), the most aggressive and treatment-resistant brain tumor. We were the first in the world to report the recruitment of endogenous Mesenchymal stem cells (MSCs) in glioma (Behnan et al. Stem Cells, 2014) and characterize the mesenchymal subtype in GBM patients (Behnan et al. Oncogene, 2017). Our observation indicated that the Mesenchymal subtype is divided into two subgroups, one induced by recruited cells and microenvironment, and another tumor cell per se expressing Mesenchymal properties suggesting brain derived MSCs/perivascular cells as the origin of the tumor origin (Behnan et al. Brain 2019; Behnan et al. Oncogene, 2017). Our particular focus is on understanding the biology of recruited noncancerous cells to the tumor, mainly primarily the immune cells and mesenchymal stem cells/perivascular progenitors in different GBM subtypes, and to. Define the origin of different recruited cell population, and its interaction with cancerous cells to solve the complexity and heterogeneity of this devastating tumors. Simultaneously, we are working on establishing a translational therapeutic treatment for GBM through combining immunotherapy with other target therapy to change the immunosuppressive microenvironment and eradicate cancer cells. With our extensive knowledge in human Glioma stem cells (Behnan et al. Sci Rep, 2016), we aim to establish drug screening library to test the specificity of drug response among different GBM subtypes. We will be using immune competent glioma mouse models, transgenic models utilizing different techniques including flow cytometry, confocal microscopy, 2 photon microscopy, low threshold ultrasound. We are looking for collaborative integrative approaches with other investigators to reach innovative treatment and achieve our ultimate goal in finding treatment for brain tumor patients. https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/1631738351461-QASVZK5T8C0VWKR8I7AL/Identification-of-a-marker-panel-that-distinguishes-sphere-cultures-from-serum-cultures_W640.jpg Behnan Lab (Copy) - Behnan Lab: Tumor Stroma I have more than 12-years’ experience in the glioma field. I did my Postdoc in the Ernfors' lab at the Karolinska Institute, Sweden. I obtained a PhD in Tumor Biology from Oslo University, Norway. I graduated from Research School in Stem Cell Biology, Lund Stem Cell Centre, Sweden, and I had Master degree in Biomedicine, Sweden. I have broad expertise in tumor stroma, preclinical trials in immunotherapy, working with epileptic and glioma patient samples and using different techniques ex. animal surgery, small animal irradiation, vaccination, Flow cytometry, confocal microscopy, and establishing primary cell culture from different human and mouse tissue. I am the leading and corresponding author on 5 of my publications. I’m serving as referee for high quality peer-reviewed journals (Brain, Stem Cells, Cancer Research, NeurOncology etc). As well, I have experience in advancing anti-inflammatory and anti-cancer treatments into clinical trials. I was awarded Marie Curie Fellowship 2019. https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847459679-XKODS8BCCXEYKBHGKJQC/20140301_Trade-151_0124-copy.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847458993-KBYNGSGUCGZWV223MRFF/20140228_Trade+151_0046.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847458319-DK4513Y3XD3GKBA1OOB6/Aro+Ha_0428.jpg Behnan Lab (Copy) https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847456616-6RFY2R4EBQWZHCZQMJE9/Aro+Ha_0010.jpg Behnan Lab (Copy) https://einsteinneurosurgery.org/himeslab daily 0.75 2024-02-27 https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/a546a4ba-254a-4ca7-bc7a-4428ba7c6f40/Himes+Profile+Pic.jpg Himes Lab - Make it stand out Dr. Benjamin T. Himes MD, PhD, MHS | Assistant Professor Department of Neurological Surgery Department of Microbiology and Immunology https://images.squarespace-cdn.com/content/v1/5f9ae16f19a58321975df924/22e5e0b0-85ec-4c54-b9f4-2fbacbcc6e28/HEPARIN+FIGURE+EV.png Himes Lab - Extracellular Vesicles in Glioblastoma Extracellular Vesicles (EVs) or Exosomes are small, lipid bilayer particles, typically less than 200 nanometers, that contain bioactive molecules including proteins and nucleic acids that shape the tumor microenvironment through intercellular interaction. EVs have been implicated in various tumorigenic processes and contribute to an immunosuppressive tumor microenvironment especially in Glioblastoma by impairing effector T cells and inducing various immunosuppressive immune cell subsets (i.e. regulatory T cells and myeloid-derived suppressor cells) and immune checkpoint markers such as PD-1/PD-L1. The Himes Lab is dedicated to characterizing the mechanisms underlying EV release, their interaction with various immune cells that contribute to the overall immunosuppressive nature of GBM, as well as their global impact on peripheral immunosuppression. https://einsteinneurosurgery.org/falcone-lab daily 0.75 2024-09-20